IISc scientists develop artificial enzymes to prevent abnormal blood clots

Researchers at the Indian Institute of Science (IISc), Bengaluru, have developed artificial enzymes—called nanozymes—that can help prevent abnormal blood clotting, particularly in cases of pulmonary thromboembolism. This life-threatening condition occurs when excessive clotting blocks the blood flow to the lungs.

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Under normal conditions, blood clotting is controlled by platelets to prevent bleeding. However, in some cases, clots can form inside blood vessels without any injury, disrupting circulation and posing serious health risks. The artificial nanozymes developed by the IISc team aim to tackle this problem by stopping such abnormal clot formation. Importantly, these nanozymes do so without generating toxic forms of oxygen that can damage tissues.

“This work lies at the intersection of chemistry and biology,” says Prof. G. Mugesh from the Department of Inorganic and Physical Chemistry at IISc. “We’re developing nanomaterials that mimic enzyme functions and testing them in biological systems. It’s a highly challenging process that demands both scientific innovation and deep commitment.”

The research reflects a significant advancement in the use of nanotechnology to address complex medical problems. As Prof. Mugesh explains, the team’s approach not only targets harmful clots but also ensures biocompatibility, making it a safer option for future therapeutic applications.